Current Studies

Current Study Timelines

Research Study Guide

S
Single Center
M
Multi Center
Ra
Randomized Controlled Trial
Ob
Observational Research
Q
Quality Assurance
D
Drug Trial
N
New Method
DC
Device Comparison
DR
Database Research
R
Recruiting
H
on Hold
C
Completed Recruitment
P
Results Published
E
Study Ended
Sp
Sponsored
LCa
Lung Cancer
ECa
Esophageal Cancer
Prospective Research Studies:
AMPLCaRe M Ra D R Sp LCa
MISGEJ S Q N R    
TM&M S Ob Q P R  
BRC 5 M Ra N R Sp LCa
TSQIC S Ob Q DR LCa  
DiVA S Ob DC R LCa  
EBUS S Ob Q N LCa  
Esophageal Database S Ob DR R ECa  
Lung Aging S N H LCa    
Retrospective Studies
tPA S Ob Q E  
REEP S Ob Q    
Pulmonary Biopsy S Ob Q N E

AFIB

S Ob Q E  
PAAL S Ob Q E  

Prospective Research Studies

AMPLCaRe – Adjuvant Melatonin for Prevention of Lung Cancer Recurrence.
This multi center double-blind randomized controlled trial Health Canada regulated study in collaboration with the Canadian College of Naturopathic Medicine is in its 4th year since conception. Sponsored by Lotte and John Hecht Foundation, the study investigates therapeutic benefits of Melatonin in prevention of lung cancer recurrence as compared to a placebo. Patients are enrolled on their first appointment after lung resection and require a 2 year follow-up. This study is actively recruiting patients.

Additional Information: To read more about Melatonin, please visit http://www.yourhealthbase.com/melatonin.htm.
ClinicalTrials.gov
Link to collection of presentations and Abstracts (coming soon)

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MISGEJ – Minimal Invasive Surgery for Gastroesophageal Junction.
This is a single center investigator driven clinical study to evaluate the short and long term impact of a fairly new Post-Approved surgical technique called minimally invasive “keyhole” surgery for Achalasia, Paraesophageal Hernia, GERD, and Zenkers Diverticulum disorders of the gastroesophageal junction. The expected study duration is 15-20 years. Although not mandatory, patients are suggested to be enrolled on their first visit after surgery. This study is actively recruiting patients.

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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TM&M – Thoracic Morbidity and Mortality Classification.
This is a single center investigator driven Observational Study for Quality Assurance with a possibility to go multi center in near future. The Division of Thoracic Surgery has pioneered a classification system for objective grading of post-surgical complications for surgical quality improvement. The TM&M Database includes Thoracic Surgical volume and post-surgical complications since January 2008. TM&M has since been evaluated for its reliability and reproducibility. TM&M Data routinely serves as a source and analyzed to help with many other research studies. In its 3rd year, we are still actively enrolling all thoracic surgical patients.

Additional Information: Ottawa Thoracic Morbidity and Mortality (TM&M) Classification System
Link to collection of presentations and Abstracts (coming soon)

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BRC5 - A Phase III Randomized Trial of Lobectomy Versus Sublobar Resection for Small (≤2 cm) Peripheral Non-Small Cell Lung Cancer.
This is a multi-center Randomized Controlled Trial sponsored by the National Cancer Institute of Canada (NCIC). The trial is in its 4th year since conception and continues to enroll new patients. Patients are consented before surgery and randomized during the operation. We are actively enrolling new patients for this trial.

Additional Information: ClinicalTrials.gov
Link to collection of presentations and Abstracts (coming soon) 

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TSQIC – Thoracic Surgery Quality monitoring, Information management, and Clinical documentation.
The Division of Thoracic Surgery is interested to test an electronic system to perform bedside iPad clinical documentation, information management and quality monitoring. At present, this is a single center initiative with the possibility of expanding to other centers in Canada. The Ottawa TMM will be incorporated into TSQIC and an observational research study for Quality Assurance will be conducted to test its efficiency. This medical informatics initiative has the ability to greatly impact the clinical practice and management of thoracic patients.

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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DiVA Study – Digital Versus Analog Pleural Drainage in Patients with Pulmonary Air Leak.
A single center Investigator driven Observational and Evaluation of Data from a Post-Approved digital medical device (Thopaz) compared to analog (Pleur-evac) in the assessment of and inter-disciplinary reliability for measuring Pulmonary Air Leak. Patients are enrolled after pulmonary surgical resection and at onset of pulmonary air leak while admitted at the hospital for post-surgical recovery. This study has recently been approved by OHREB. The study is expected to start new patient enrollment in October 2011.

Additional Information: ThopazTM (Medela), Pleur-evacR (Teleflex)
Link to collection of presentations and Abstracts (coming soon)

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EBUS – Evaluation of Endobronchial Ultrasound for Staging Lung Cancer.
This single centre investigator driven Observational research study for Quality Assurance is a collaboration with the Radiology and Pathology Departments at TOH to compare results of EBUS-TBNA to the findings of mediastinoscopy. Other Diagnostic tests such as CT and PET will also be used to compare our results. Patient enrollment will be performed before surgery. It is expected to begin recruiting in October 2011.

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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Esophageal Database - Evaluating the impact of changing practice patterns in the treatment of esophagogastric cancer at the Ottawa Hospital.
A single center retrospective and prospective investigator driven Observational study involving Chart Review and collection of health data in Thoracic Esophageal Database using available information from TOHRCC MOSAIC-Rad Onc, TMM and CAC patient tracking databases to investigate the health conditions of esophageal cancer and Barrett’s Esophagus patients and to evaluate the current clinical practice, especially neoadjuvant chemo/rad before esophageal resection, for such diagnoses. This is an ongoing database research study selecting patients starting from January 1st 2000 and does not have an end time.

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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Lung Aging - A Microarray Analysis of Young and Aged Human Lung Tissue to Determine Lung Cancer Genetic Susceptibility Profiles
This single center investigator driven research study is testing a new technique known as micro-array analysis for genetic susceptibility profiles of lung cancer. Patient recruitment has begun although the study is currently on hold pending clarification of logistical issues involving lab space and collection of tissue samples.

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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Retrospective Research Studies:

tPA - Managing complicated pleural effusion with intrapleural fibrinolysis: The Ottawa Hospital experience.
This is a single centre Observational study involving Chart Reviews for Quality Assurance. The aim of the clinical study is to review the experience of using intrapleural fibrinolytic agents in certain thoracic surgery principles for management of complicated pleural effusion (CPE). Data acquisition and analysis has been completed. The results will be soon published.

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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REEP – Review of Esophagectomies for Esophageal Perforations. A Necessary Salvage Procedure.
A single centre Observational study for Quality Assurance that will include Chart Review of Ottawa Hospital health records to investigate cases about the management of esophageal perforations since July 1983 to July 2011. Considered as one of the largest time periods for such an investigation, this one year study is expected to start data acquisition in October 2011. 

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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Pulmonary Biopsy – Evaluating the Impact of Routine Percutaneous Biopsy on the Outcomes of Thoracic Surgical Procedures: A Retrospective 2 Year Review at the Ottawa Hospital.
A single center Observational study for Quality Assurance using Chart Reviews and data from TMM. In collaboration with the Department of Radiology at TOH, the study has aims to investigate practice of routine percutaneous biopsy for pulmonary nodules, determine rates of negative percutaneous biopsy in lung nodules suspicious for malignancy, and disclose time delays, if any, in definitive treatment after routine biopsies. Patients were selected starting from January 2008 to May 2010. Data acquisition has been completed.

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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AFIB - Documenting the burden of post-operative atrial fibrillation after pulmonary resection using a novel system to classify severity of post-operative complications.
This single centre Observational Study for Quality Assurance used Chart Reviews and TMM data to investigate pre-operative risk factors, co-morbidities, and mortality for Atrial Fibrillation. Patients were selected over a period since Jan 2008 to Jan 2010. Data acquisition and analysis was recently completed and results will be soon published.

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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PAAL - Documenting the burden of post-operative air leak after pulmonary resection using a novel system to classify severity of post-operative complications.
This single centre Observational Study for Quality Assurance used Chart Reviews and TMM data to investigate pre-operative risk factors, co-morbidities, and mortality for Pulmonary Air Leak. Patients were selected over a period since Jan 2008 to Jan 2010. Data acquisition and analysis was recently completed and results will be soon published.

Additional Information: Link to collection of presentations and Abstracts (coming soon)

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