Selected Publications

  1.

Vanderluit JL, Wylie C, Ghanem N, McClellan KA, Fortin A, Callaghan SM, MacLaurin JG , Park DS, Slack RS . The Retinoblastoma family member, p107 regulates the rate of progenitor commitment to a neuronal fate. J. Cell Biol. (2007 - Accepted)

 
  2.

Ruzhynsky V, McClellan K, Vanderluit J , Jeong Y, Furimsky M, Park DS, Epstein D, Wallace V, Slack RS . Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon. J. Neuroscience (in press)

 
  3.

McClellan KA, Douda DN, Ruzhynsky VA, Vanderluit JL, Ferguson KL, Chen D, Bremner R, Park DS, Leone G, Slack RS . A unique cell cycle independent role in regulating neuronal migration in vivo. Mol. Cell Biol. (2007) Apr 23; [Epub ahead of print].

 
  4.

Cheung ECC, McBride HM and Slack RS . Mitochondrial dynamics in the regulation of neuronal cell death. Apoptosis (2007) May;12(5):979-92.Review.

 
  5. Cheung EC, Joza N, Steenaart NA, McClellan KA, Neuspiel M, McNamara S, Maclaurin JG, Rippstein P, Park DS, Shore GC, McBride HM, Penninger JM, Slack RS. Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J. 2006 Sep 6;25(17):4061-73.

  6. McClellan KA, Slack RS. Novel functions for cell cycle genes in nervous system development. Cell Cycle. 2006 Jul;5(14):1506-13.

  7. Ferguson KL, McClellan KA, Vanderluit JL, McIntosh WC, Schuurmans C, Polleux F, Slack RS. A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration. EMBO J. 2005.

  8. Eric C. C. Cheung, Lysanne Melanson-Drapeau, Sean P. Cregan, Jacqueline L. Vanderluit, Kerry L. Ferguson, William C. McIntosh, David S. Park, Steffany A. L. Bennett, and Ruth S. Slack. AIF is a key factor in neuronal cell death Propagated by Bax-dependent and Bax-independent mechanisms. J Neurosci. 2005.

  9. Sean P. Cregan, Nicole A. Arbour , Jason G. MacLaurin, Steven M. Callaghan, Andre Fortin, Eric C. C. Cheung, Daniel S. Guberman, David S. Park and Ruth S. Slack. p53 activation domain 1 is essential for puma upregulation and p53-mediated neuronal cell death. J Neurosci. (2004)

  10. Cheung EC and Slack RS. Kinases better known for regulating growth and survival turn deadly in a model neuronal cell death. Sci. STKE pe45 (2004).

  11. Vanderluit JL, Ferguson KL, Nikoletopoulou V, Parker M, Ruzhynsky V, Alexson T, McNamara SM, Park DS, Rudnicki M, Slack RS. p107 regulates neural precursor cells in the mammalian brain. J Cell Biol. 2004 Sep 13;166(6):853-63.
  12. Chen D, Livne-Bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell. 2004 Jun;5(6):539-551.
  13. Fortin A, MacLaurin JG, Arbour N, Cregan SP, Kushwaha N, Callaghan SM, Park DS, Albert PR, Slack RS. The Proapoptotic Gene SIVA Is a Direct Transcriptional Target for the Tumor Suppressors p53 and E2F1. J Biol Chem. 2004 Jul 2;279(27):28706-14. Epub 2004 Apr 22.
  14. Cregan SP, Dawson VL, Slack RS. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene. 2004 Apr 12;23(16):2785-96.
  15. Cregan SP, Fortin A, MacLaurin JG, Callaghan SM, Cecconi F, Yu SW, Dawson TM, Dawson VL, Park DS, Kroemer G, Slack RS. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol. 2002 Aug 5; 158(3): 507-17. Epub 2002 Jul 29.
  16. Ferguson KL, Vanderluit JL, Hebert JM, McIntosh WC, Tibbo E, MacLaurin JG, Park DS, Wallace VA, Vooijs M, McConnell SK, Slack RS. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J. 2002 Jul 1; 21(13): 3337-46.
  17. Fortin A, Cregan SP, MacLaurin JG, Kushwaha N, Hickman ES, Thompson CS, Hakim A, Albert PR, Cecconi F, Helin K, Park DS, Slack RS. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol. 2001 Oct 15; 155(2):207-16. Epub 2001 Oct 08.
  18. Simpson MT, MacLaurin JG, Xu D, Ferguson KL, Vanderluit JL, Davoli MA, Roy S, Nicholson DW, Robertson GS, Park DS, Slack RS. Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J Neurosci. 2001 Sep 15; 21(18): 7089-98.
  19. Ferguson KL, Slack RS. The Rb pathway in neurogenesis. Neuroreport. 2001 Jul 3; 12(9): A55-62. Review.
  20. Ferguson KL, Callaghan SM, O'Hare MJ, Park DS, Slack RS. The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulation. J Biol Chem. 2000 Oct 27; 275(43): 33593-600.
  21. Cregan SP, MacLaurin JG, Craig CG, Robertson GS, Nicholson DW, Park DS, Slack RS. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J Neurosci. 1999 Sep 15; 19(18): 7860-9.
     

Publications

  18. Zhang Y, Qu D, Morris EJ, O'Hare MJ, Callaghan SM, Slack RS, Geller HM, Park DS. The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin. J Neurosci. 2006 Aug 23;26(34):8819-28.

  19. Kennedy CR, Xiong H, Rahal S, Vanderluit J, Slack RS, Zhang Y, Guan Y, Breyer MD, Hebert RL. Urine Concentrating Defect in Prostaglandin EP1-Deficient Mice. Am J Physiol Renal Physiol. 2006 Aug 1.

  20. Smith PD, Mount MP, Shree R, Callaghan S, Slack RS, Anisman H, Vincent I, Wang X, Mao Z, Park DS. Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. J Neurosci. 2006 Jan 11;26(2):440-7.

  21. Crocker SJ, Hayley SP, Smith PD, Mount MP, Lamba WR, Callaghan SM, Slack RS, Park DS. Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase. J Neurochem. 2006 Jan;96(2):489-99.

  22. O'Hare MJ, Kushwaha N, Zhang Y, Aleyasin H, Callaghan SM, Slack RS, Albert PR, Vincent I, Park DS. Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. J Neurosci. 2005 Sep 28;25(39):8954-66.

  23. Rashidian J, Iyirhiaro G, Aleyasin H, Rios M, Vincent I, Callaghan S, Bland RJ, Slack RS, During MJ, Park DS. Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14080-5. Epub 2005 Sep 15.

  24. Berube NG, Mangelsdorf M, Jagla M, Vanderluit J, Garrick D, Gibbons RJ, Higgs DR, Slack RS, Picketts DJ. The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest. 2005 Feb;115(2):258-67.

  25. Keramaris E, Vanderluit JL, Bahadori M, Mousavi K, Davis RJ, Flavell R, Slack RS, Park DS. c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. J Biol Chem. 2005 Jan 14;280(2):1132-41. Epub 2004 Nov 4.

  26. Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, Anisman H, Park DS. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23): 13650-5. Epub 2003 Oct 31.

  27. Keramaris E, Hirao A, Slack RS, Mak TW, Park DS. Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage. J Biol Chem. 2003 Sep 26; 278(39): 37782-9. Epub 2003 Jul 11.

  28. Ferguson KL, Slack RS. Growth factors: can they promote neurogenesis? Trends Neurosci. 2003 Jun; 26(6): 283-5. Review.
  29. Crocker SJ, Smith PD, Jackson-Lewis V, Lamba WR, Hayley SP, Grimm E, Callaghan SM, Slack RS, Melloni E, Przedborski S, Robertson GS, Anisman H, Merali Z, Park DS. Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. J Neurosci. 2003 May 15; 23(10): 4081-91.

  30. Sedarous M, Keramaris E, O'Hare M, Melloni E, Slack RS, Elce JS, Greer PA,Park DS. Calpains mediate p53 activation and neuronal death evoked by DNA damage. J Biol Chem. 2003 Jul 11; 278(28): 26031-8. Epub 2003 Apr 29.

  31. Fernando P, Kelly JF, Balazsi K, Slack RS, Megeney LA. Caspase 3 activity is required for skeletal muscle differentiation. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17): 11025-30. Epub 2002 Aug 12.

  32. Cregan SP, Fortin A, MacLaurin JG, Callaghan SM, Cecconi F, Yu SW, Dawson TM, Dawson VL, Park DS, Kroemer G, Slack RS. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol. 2002 Aug 5; 158(3): 507-17. Epub 2002 Jul 29.

  33. Ferguson KL, Vanderluit JL, Hebert JM, McIntosh WC, Tibbo E, MacLaurin JG, Park DS, Wallace VA, Vooijs M, McConnell SK, Slack RS. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J. 2002 Jul 1; 21(13): 3337-46.
  34. Ghahremani MH, Keramaris E, Shree T, Xia Z, Davis RJ, Flavell R, Slack RS, Park DS. Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. J Biol Chem. 2002 Sep 20; 277(38): 35586-96. Epub 2002 Jun 28.
  35. Maier JK, Lahoua Z, Gendron NH, Fetni R, Johnston A, Davoodi J, Rasper D, Roy S, Slack RS, Nicholson DW, MacKenzie AE. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. J Neurosci. 2002 Mar 15; 22(6): 2035-43.

  36. Wang F, Corbett D, Osuga H, Osuga S, Ikeda JE, Slack RS, Hogan MJ, Hakim AM, Park DS.  Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat. J Cereb Blood Flow Metab. 2002 Feb; 22(2): 171-82.

  37. Crocker SJ, Lamba WR, Smith PD, Callaghan SM, Slack RS, Anisman H, Park DS. c-Jun mediates axotomy-induced dopamine neuron death in vivo. Proc Natl Acad Sci U S A. 2001 Nov 6; 98(23): 13385-90. Epub 2001 Oct 30.

  38. Fortin A, Cregan SP, MacLaurin JG, Kushwaha N, Hickman ES, Thompson CS, Hakim A, Albert PR, Cecconi F, Helin K, Park DS, Slack RS. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol. 2001 Oct 15; 155(2): 207-16. Epub 2001 Oct 08.

  39. Simpson MT, MacLaurin JG, Xu D, Ferguson KL, Vanderluit JL, Davoli MA, Roy S, Nicholson DW, Robertson GS, Park DS, Slack RS. Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J Neurosci. 2001 Sep 15; 21(18): 7089-98.

  40. Morris EJ, Keramaris E, Rideout HJ, Slack RS, Dyson NJ, Stefanis L, Park DS.  Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage. J Neurosci. 2001 Jul 15; 21(14): 5017-26.

  41. Ferguson KL, Slack RS. The Rb pathway in neurogenesis. Neuroreport. 2001 Jul 3; 12(9): A55-62. Review.

  42. Osuga H, Osuga S, Wang F, Fetni R, Hogan MJ, Slack RS, Hakim AM, Ikeda JE, Park DS. Cyclin-dependent kinases as a therapeutic target for stroke. Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18): 10254-9.

  43. Cregan SP, MacLaurin JG, Gendron TF, Callaghan SM, Park DS, Parks RJ, Graham FL, Morley P, Slack RS. Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons. Gene Ther. 2000 Jul; 7(14): 1200-9.

  44. Ferguson KL, Callaghan SM, O'Hare MJ, Park DS, Slack RS. The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulation. J Biol Chem. 2000 Oct 27; 275(43): 33593-600.

  45. O'Hare MJ, Hou ST, Morris EJ, Cregan SP, Xu Q, Slack RS, Park DS. Induction and modulation of cerebellar granule neuron death by E2F-1. J Biol Chem. 2000 Aug 18; 275(33): 25358-64.

  46. Keramaris E, Stefanis L, MacLaurin JG, Harada N, Takaku K, Ishikawa T, Taketo MM, Robertson GS, Nicholson DW, Slack RS, Park DS.  Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage. Mol Cell Neurosci. 2000 Apr; 15(4): 368-79.

  47. Giovanni A, Keramaris E, Morris EJ, Hou ST, O'Hare M, Dyson N, Robertson GS, Slack RS, Park DS.  E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3 . J Biol Chem. 2000 Apr 21; 275(16): 11553-60.

  48. Cregan SP, MacLaurin JG, Craig CG, Robertson GS, Nicholson DW, Park DS, Slack RS. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J Neurosci. 1999 Sep 15; 19(18): 7860-9.

  49. Callaghan DA, Dong L, Callaghan SM, Hou YX, Dagnino L, Slack RS. Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity. Dev Biol. 1999 Mar 15; 207(2): 257-70.
  50. Slack RS, El-Bizri H, Wong J, Belliveau DJ, Miller FD. A critical temporal requirement for the retinoblastoma protein family during neuronal determination. J Cell Biol. 1998 Mar 23; 140(6): 1497-509.

  51. Slack RS, Belliveau DJ, Rosenberg M, Atwal J, Lochmuller H, Aloyz R, Haghighi A, Lach B, Seth P, Cooper E, Miller FD. Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons. J Cell Biol. 1996 Nov; 135(4): 1085-96.

  52. Slack RS, Miller FD. Viral vectors for modulating gene expression in neurons. Curr Opin Neurobiol. 1996 Oct; 6(5): 576-83. Review.

  53. Slack RS, Miller FD. Retinoblastoma gene in mouse neural development. Dev Genet. 1996; 18(1): 81-91. Review.
  54. Slack RS, Skerjanc IS, Lach B, Craig J, Jardine K, McBurney MW. Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins. J Cell Biol. 1995 May; 129(3): 779-88.
  55. Slack RS, Craig J, Costa S, McBurney MW. A denovirus 5 E1A induced differentiation of P19 embryonal carcinoma cells requires binding to p300. Oncogene. 1995 Jan 5; 10(1): 19-25.
  56. Skerjanc IS, Slack RS, McBurney MW. Cellular aggregation enhances MyoD-directed skeletal myogenesis in embryonal carcinoma cells. Mol Cell Biol. 1994 Dec; 14(12): 8451-9.
  57. Slack RS, Hamel PA, Bladon TS, Gill RM, McBurney MW. Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells. Oncogene. 1993 Jun; 8(6): 1585-91.
  58. Slack RS, Proulx P. Effects of retinoic acid and staurosporine on the protein kinase C activity and the morphology of two related human neuroblastoma cell lines. Biochim Biophys Acta. 1990 Jun 12; 1053(1): 89-96.

 

Copyright © 2006 Ruth Slack, University of Ottawa.