Contact Information

Ruth S. Slack, Ph.D Professor Department of Cellular and Molecular Medicine
Faculty of Medicine University of Ottawa
451 Smyth Road,
Room 3510B (Lab: 3522)
Ottawa, Ontario, Canada
K1H 8M5

Publications

  • Svoboda, D.S., Clark, A., Park, D.S., and Slack, R.S. (2015). Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models. J. Vis. Exp. (95), e51983.

  • Patten, D.A., Wong, J., Khacho, M., Soubannier, V., Mailloux, R.J., Pilon-Larose, K., MacLaurin, J.G., Park, D.S., McBride, H.M., Trinkle-Mulcahy, L., and Slack, R.S. (2014). OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. Embo J. 33, 2676–2691.

  • Khacho, M., Tarabay, M., Patten, D., Khacho, P., MacLaurin, J.G., Guadagno, J., Bergeron, R., Cregan, S.P., Harper, M.-E., Park, D.S., and Slack, R.S. (2014). Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival. Nature Communications 5, 3550.

  • Germain, M., Nguyen, A.P., Khacho, M., Patten, D.A., Screaton, R.A., Park, D.S., and Slack, R.S. (2013). LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction. Hum. Mol. Genet. 22, 952–962.

  • Svoboda, D.S., Paquin, A., Park, D.S., and Slack, R.S. (2013). Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis. Developmental biology 384, 101-113.

  • Julian, L.M., Vandenbosch, R., Pakenham, C.A., Andrusiak, M.G., Nguyen, A.P., McClellan, K.A., Svoboda, D.S., Lagace, D.C., et al. and Slack, R.S. (2013). Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells. Cell stem cell 12, 440-452.

  • Germain, M., Nguyen, A.P., Khacho, M., Patten, D.A., Screaton, R.A., Park, D.S., and Slack, R.S. (2013). LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction. Human molecular genetics 22, 952-962.

  • Andrusiak, M.G., Vandenbosch, R., Dick, F.A., Park, D.S., and Slack, R.S. (2013). LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence. Cell cycle (Georgetown, Tex) 12, 1416-1423.

  • Ghanem, N., Andrusiak, M.G., Svoboda, D., Al Lafi, S.M., Julian, L.M., McClellan, K.A., De Repentigny, Y., Kothary, R., et al. and Slack, R.S. (2012). The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster. The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 8219-8230.

  • Andrusiak, M.G., Vandenbosch, R., Park, D.S., and Slack, R.S. (2012). The retinoblastoma protein is essential for survival of postmitotic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 14809-14814.

  • Jahani-Asl, A., Pilon-Larose, K., Xu, W., MacLaurin, J.G., Park, D.S., McBride, H.M., and Slack, R.S. (2011). The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity. The Journal of biological chemistry 286, 4772-4782.

  • Germain, M., and Slack, R.S. (2011). MCL-1 regulates the balance between autophagy and apoptosis. Autophagy 7, 549-551.

  • Germain, M., Nguyen, A.P., Le Grand, J.N., Arbour, N., Vanderluit, J.L., Park, D.S., Opferman, J.T., and Slack, R.S. (2011). MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. The EMBO journal 30, 395-407.

  • Andrusiak, M.G., McClellan, K.A., Dugal-Tessier, D., Julian, L.M., Rodrigues, S.P., Park, D.S., Kennedy, T.E., and Slack, R.S. (2011). Rb/E2F regulates expression of neogenin during neuronal migration. Molecular and cellular biology 31, 238-247.

  • Patten, D.A., Germain, M., Kelly, M.A., and Slack, R.S. (2010). Reactive oxygen species: stuck in the middle of neurodegeneration. Journal of Alzheimer's disease : JAD 20 Suppl 2, S357-367.

  • Jahani-Asl, A., Germain, M., and Slack, R.S. (2010). Mitochondria: joining forces to thwart cell death. Biochimica et biophysica acta 1802, 162-166.

  • Germain, M., and Slack, R.S. (2010). Dining in with BCL-2: new guests at the autophagy table. Clinical science (London, England : 1979) 118, 173-181.

  • Ruzhynsky, V.A., Furimsky, M., Park, D.S., Wallace, V.A., and Slack, R.S. (2009). E2F4 is required for early eye patterning. Developmental neuroscience 31, 238-246.

  • McClellan, K.A., Vanderluit, J.L., Julian, L.M., Andrusiak, M.G., Dugal-Tessier, D., Park, D.S., and Slack, R.S. (2009). The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. Molecular and cellular biology 29, 4701-4713.

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Last updated: 2015.05.25