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  The site should be prepped with iodinated solution, unless an allergy to iodine exists. Application is usually in a circular fashion, starting from the planned needle insertion point and encompassing the interspace above and below. Apply the solution at least three times. The last application is followed by an application of isopropyl alcohol or a chlorhexidene based solution to wash off the iodinated solution. The iodinated solution must be carefully removed because the inadvertent introduction of iodine into the subarachnoid space can produce an irritative arachnoiditis.
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