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Erling W. Rud, M.Sc. (Quebec), Ph.D. (Ottawa)
Adjunct Professor
Department of Pathology and Laboratory Medicine
Faculty of Medicine.
Senior Science Advisor / Conseiller scientifique principal
Bureau of Microbial Hazards/Bureau des dangers microbiens
Food Directorate/Directions des aliments
HEALTH CANADA/SANTÉ CANADA
251 Sir Frederick Banting Driveway
A.L. 2203B. Room/pièce B300-03
Ottawa, Ontario Canada. K1A 0K9
Tel: 613-960-5615
Fax: 613-954-1198
Email: erling.rud@hc-sc.gc.ca
Web Sites:
https://www.linkedin.com/in/erlingrud
https://www.researchgate.net/profile/Erling_Rud
Research Interests
- Molecular Virology
- Viral Vaccines
- Retrovirus Diagnostics
- Retroviral Pathogenesis
- Animal Models for HIV
- Animal models for emerging disease (Viral and Bacteriolgical).
- Viral variation in response to antiviral therapy and vaccination.
- Viral vaccine strategies and how to improve effificacy and safety.
- Host genomics and its relationship to infectious diseases.
- Cynomolgus macaques as host to test antiviral and vaccine prophylactics.
- Viral Zoonotic infections among handlers of Nonhuman Primates.
Since returning from working with Wellcome Research Laboratories, UK (now part of GlaxoSmithKline Inc) in 1994, I have been exploring the use of the SIV/macaque model for HIV vaccine development and studies on SIV mediated pathogenesis as a model for HIV pathogenesis in humans (Funded by the National AIDS Strategy from 1994-2001). From 2001 to 2007 our work involved the use of gene chips (immunochips) and Real time PCR to look at early immune response genes which are up or down regulated after a vaccinated individual is challenged with a highly pathogenic challenge virus (a collaborative project with Dr David Kelvin, University of Toronto, funded by Health Canada, Genome Canada and CANVAC/NCE). We have also collaborated with the US CDC on a surveillance program for evidence of Retroviral infections amongst workers occupationally exposed to Nonhuman Primates.
Since returning to the Food Directorate in 2009, my research interests have expanded to the use of genomic approaches to detect and identify food microbes (Viral, Bacterial and Parasite) and better understand the Microbiome associated with food.
Recent Publications
- Rud, E. W., T.U. Vogel, A. Sherring, D. Bogdanovic, D. Ko, J. Mihowich, M. Parenteau, N. J. Edgar, K. A. Reimann, N.L. Letvin, M. P. Cranage and J. Fournier (2011). Infection with the attenuated SIVmacC8 does not protect against superinfection with SIVsmmPBj14 nor SHIV89.6P but provides long-term protection against onset of disease. (in preparation).
- Rud, E. W., D. Ko , T.U. Vogel, A. Sherring, D. Bogdanovic, J. Mihowich and J. Fournier (2011). Differential Nef evolution correlates to rate of disease progression in cynomolgus macaques infected with wild type and attenuated SIV. (in preparation).
- Salha, M.D., R. Cheynier, H. McGrath, T.Y. Langaee, B. Yassine-Daib, H. Soudeyns, J. Fournier, M. Parenteau, J. Edgar, D. Ko, A. Sherring, D. Boganovic, R.-P. Sekaly and E.W. Rud (2011). Expansions and exhaustions of the CD4 T cell repertoire during primary infection predict disease progression in SIV infected cynomolgus macaques. (in preparation).
- Bosinger, S.E., A. Danesh, L. Xu, A. Sidahmed, L. Ran, M. Parenteau, J. Fournier, B.P. Lee, D. KoM.J. Cameron, L. Zhang, D.J. Kelvin and E.W. Rud (2011). Live attenuated Lentiviral vaccine induced protection against intravenous challenge with pathogenic SHIV89.6P is associated with maintenance of Toll-like Receptor expression and Interferon induced gene expression. (Rewriting for resubmission)
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