Contact Information
Manon Levesque Departmental Secretary of Pathology and Laboratory Medicine
451 Smyth road,
Room 4155
Ottawa, Ontario
CANADA K1H 8M5 Telephone: 613-562-5422
Fax: 613-562-5442

Sheila Schnupp
Office and Residency Program Administrator (Anatomical and General Pathology)
Telephone: 613-562-5800 x8342
Fax: 613-562-5442

John P. Veinot, M.D., F.R.C.P.C (Canada)
Chairman, Department of Pathology and Laboratory Medicine
Tel: 613-562-5422
Fax: 613-562-5442

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Adolfo J. de Bold

B.Sc.(Cord.), M.Sc.(Queen's), Ph.D.(ibid.), F.R.S.C., F.R.C.P.(Hon.)
Full Professor, Department of Pathology and Laboratory Medicine, Faculty of Medicine.
Cross-appointed Professor, Department of Cellular and Molecular Medicine, Faculty of Medicine.
Member, Faculty of Graduate and Postdoctoral Studies, University of Ottawa.
Director, Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, 40 Ruskin St. Ottawa, Ontario, K1Y 4W7, Canada.

Telephone: (613) 761 4265
Fax: (613) 761 1597

Areas of Interest and Expertise

  • Synthesis & Mechanism of action of ANF and BNP and their relation to hypertension and congestive heart failure.
  • Light and electron microscopy.
  • Dosage of polypeptide hormones.
  • Molecular biology.
  • In vivo, in vitro models of disease.

Recent Publications

  • PLC signaling tonically represses basal atrial natriuretic factor (ANF) secretion from the atria of the heart. Chang, A.I.  and deBold, A.J. Submitted for publication, 2009.
  • The Cardiac Hormones ANF and BNP Modulate Proliferation in the Unidirectional Mixed Lymphocyte Reaction. Kuroski deBold, M.L., Etchepare, A.,  Martinuk, A. and deBold, A.J.
    J.Heart Lung.Transplant.  Accepted for publication, 2009.
  • Invited Editorial: Cardiac natriuretic peptides: gaining further insights into structure-function relationships. deBold, A.J. 
    J. Am. Coll. Cardiol., In press, 2009.
  • Transcriptional Analysis of the Heart with Special Reference to its Endocrine Function.
    McGrath, M.F., Kuroski deBold, M.L. and deBold, A.J
    BMC Genomics 10:254, 2009
  • Role of potassium channels in stretch-promoted atrial natriuretic factor (ANF) secretion
    Ogawa, T., Forero, M., Burgon, P.G., Kuroski deBold, M.L., Georgalis,T. and deBold, A.J.
    J.Am.Soc.Hyperten. 3: 9-18,  2009
  • Cardiac Natriuretic Peptides Gene Expression and Secretion in Inflammation
    deBold, A.J.
    Invest. Med.  2009 57: 29-32, 2009
  • Angiotensin II Receptor Antagonism Reverts Cardiac BNP Upregulation and Secretion Observed in Myocarditis
    Ogawa, T, Veinot, J. P., Georgalis, T. and deBold, A. J.
    Am.J.Physiol. 294: H5296, 2008
  • Relationship between Natriuretic Peptides and Inflammation. Proteomic Evidence Obtained during Acute Cardiac Allograft Rejection in Humans
    Meirovich, Y. F.,  Veinot, J. P., Kuroski deBold, M. L.,  Haddad, H., Davies, R.A., Masters, R. G., Hendry, P. J. and deBold, A.J.
    J.Heart Lung Transplant. 27:31-7. 2008
  • Determinants of Brain Natriuretic Peptide (BNP) Gene Expression and Secretion in Acute Cardiac Allograft Rejection.
    deBold, A.J. 
    Current Opinions in Cardiology 22: 146-150, 2007
  • Gene Expression, Processing and Secretion of Natriuretic Peptides.  Physiological and Diagnostic Implications
    Ramos, H. and deBold, A.J.
    Clinics of North America, Heart Failure Clinics 2 (3): 255, 2006
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Last updated: 2011.07.04