Clinical history: This is an 85 year old woman who underwent an open cholecystectomy and liver margin resection for suspicion of a gallbladder cancer on imaging.
What is your diagnosis?
Discussion and answer
Florid Proliferation of Luschka Ducts
Within the perimuscular soft tissue adjacent to the liver, there is a
proliferation of bile ductules associated with acute inflammation and
fibrinous adhesion, consistent with a florid proliferation of Luschka
ducts. The differential diagnosis includes a well differentiated
adenocarcinoma. The proliferation of these small ducts
is limited to the the soft tissue between the gallbladder and the liver,
no mucosal origin is seen microscopically and grossly, no significant
atypia is identified, and no perineural invasion is identified, consistent
with Luschka ducts which are believed to be embryologic remnants of the
embryonic primordium of the liver.