Dr. Shahrier Amin

Resident PGY4

Case Four

Overview

Clinical history: 35 year old male with enlarged neck lymph nodes

Microscopic Description:

Sections of this biopsy show a portion of lymph node and fat as well as skeletal muscle. There is a diffusely infiltrating lesion composed of uniform intermediate size lymphocytes with a starry sky background of tingible body macrophages. Mitotic activity is extremely high.

Using the paraffin block provided immunophenotyping shows the tumor cell population to mark with CD10, CD20, bcl-6. Labeling with Ki-67 is essentially 100%. BCL-2 is negative as is CD3, CD5, CD30, CD23, MUM-1, cyclin D1. This immunophenotype in combination with the morphologic features is characteristic of Burkitt lymphoma.

59-year-old male presents previous history of lymphoma presents with enlarged right axillary lymph node

SPECIMEN SOURCE: Right axillar lymph nodes
CLINICAL HISTORY: Lymphoma

What is the most probable diagnosis?


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