Clinical history: 26 year old woman undergoing routine pap screening.
What is your diagnosis?
Discussion and answer
The initial LBP demonstrates hypercellular groupings of overlapping squamous cells with moderate amounts of cytoplasm. The nuclei are pleomorphic and demonstrate irregular contours. Case signed out as ASC-H.
Subsequent biopsy of cervix demonstrates a small focus at the edge of HSIL. High power view full thickness atypia with loss of maturation.