Clinical history: A 58 year old lady presents with a left renal mass. A radical nephrectomy was done. The surgical specimen consisted of left kidney containing a well circumscribed mass with a solid, tan to brown cut surface.
What is your diagnosis?
What is the diagnosis?
Microscopically, the lesion consists of nests of cells with low grade, small round to larger rasinoid nuclei showing scant mitotic activity. Nuclear grooves are also present. A perinuclear clear halo is identified in most of the cells. The cytoplasm is abundant and has a pale, reticular appearance. Necrosis is not identified.
Chromophobe type, renal cell carcinoma
Chromophobe carcinoma constitutes about 5% of adult renal epithelial tumours, with no gender preference. The mean age is 51 years. They usually have a good prognosis.
The chromophobe carcinoma is usually well circumscribed and confined within the renal capsule. Microscopically the tumour shows nests of cells with low grade nuclei, nuclear grooves and scant mitotic activity. The cells have either abundant, pale and reticular (flocculent) cytoplasm or scanty eosinophilic granular cytoplasm. Presence of perinuclear halo is a characteristic feature. The perinuclear halo can be highlighted with colloidal iron, histochemical stain.