Clinical history: 52 year old male with cough, dyspnea, weight loss.
What is the most probable diagnosis?
Large Cell Neuroendocrine Carcinoma.
Large cell neuroendocrine carcinoma of the lung is a variant of large cell carcinoma. Large cell carcinomas are undifferentiated malignant epithelial tumours that lack
the cytologic features of small-cell carcinoma and glandular or squamous differentiation. The cells typically have large nuclei, prominent nucleoli,
and a moderate amount of cytoplasm. The neuroendocrine variant is recognized by such features as organoid nesting, trabecular, rosette-like, and palisading patterns.
These features suggest neuroendocrine differentiation, which can be confirmed by immunohistochemistry or electron microscopy.