CORBETT, Dale, Ph.D.
Faculty of Medicine
451 Smyth Road, Ottawa, ON
Tel.: 613-562-5800 ext. 8177
In Canada there are ~50,000 strokes per year. A majority of stroke survivors are left with life long disabilities making stroke the leading cause of permanent neurological disability. Recent findings suggest that stroke injury triggers restorative processes to create a cerebral milieu similar to that of early brain development, a period characterized by rapid neuronal growth and neuroplasticity. In my lab we attempt to optimally engage these neuroplasticity/re-organizational processes to better enhance post-stroke recovery of function. We use sophisticated animal models of stroke that lend themselves to clinical translation. Examples of current research projects:
- Mobilizing endogenous stem and neuronal precursor cells (NPCs) in animals that have experienced stroke. The aim is to encourage NPCs to migrate to the injury site and reorganize remaining circuitry to take over lost function
- Use of novel drug delivery systems and nanotechnology to deliver growth factors and recovery promoting drugs to brain areas thought to be critical for mediating recovery of function
- Exercise effects on neurogenesis, angiogenesis and cognitive function
- Development of an animal model of vascular cognitive impairment characterized by executive dysfunction
- Influence of unhealthy diets (i.e. high fat, sugar and sodium) and physical inactivity on the cerebrovasculature and immune system and ultimate impacts on stroke severity and post-stroke recovery of sensory-motor and cognitive function.
CIHR; Canadian Stroke Network; Heart & Stroke Foundation of Canada; NSERC; Heart & Stroke Foundation Centre for Stroke Recovery.
- Krakauer J, Carmichael ST, Corbett D, Wittenberg G Getting neurorehabilitation right – What can we learn from animal models? Neurorehabil & Neural Repair, 2012, 26, 923-931.
- Langdon KD, Corbett D Improved working memory following novel combinations of physical and cognitive activity. Neurorehabil & Neural Repair, 2012, 26, 523-532.
- MacLellan CL, Keough MB, Granter-Button S, Chernenko GA, Butt S, Corbett D A critical threshold of rehabilitation involving brain-derived neurotrophic factor is required for post-stroke recovery. Neurorehabil & Neural Repair, 2011, 25, 740-748.
- Langdon KD, Clarke J, Corbett D Long-term exposure to high fat diets are bad for your brain: Exacerbation of focal ischemic injury. Neuroscience, 2011, 182, 82-87.
- Langdon KD, MacLellan CL, Corbett D Prolonged, 24-hour delayed peripheral inflammation increases short- and long-term functional impairment and histopathological damage following focal ischemia in the rat. J Cereb Blood Flow Metab, 2010, 1450-1459.
- Wang Y, Cooke, MJ, Lapitsky Y, Wylie RG, Sachewsky N, Corbett D, Morshead CM, Shoichet MS Transport of epidermal growth factor in stroke-injured brain. J Control Release, 2010, 149, 225-235.
- Ploughman M, Windle V, White N, MacLellan CL, Doré JJE, Corbett D Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke, 2009, 40, 1490-1495.
- Murphy TH, Corbett D Plasticity during stroke recovery: from synapse to behavior. Nat Rev Neurosci, 2009, 10, 861-872.
- Clarke J, Mala H, Windle V, Chernenko G, Corbett D The effects of repeated rehabilitation “Tune-Ups” on functional recovery after stroke. Neurorehabil & Neural Repair, 2009, 23, 886-894.
- Hicks AU, Lappalainen RS, Narkilahti S, Suuronen R, Corbett D, Sivenius J, Jolkkonen J, Hovatta O The effects of transplantation of human embryonic stem cell derived neural precursor cells after cortical stroke in rats. Eur J Neurosci 2009, 29, 562-574.
- Hicks AU, Hewlett K, Windle V, Chernenko G, Ploughman M, Jolkkonen J, Weiss S, Corbett D. Enriched environment enhances transplanted SVZ stem cell survival, migration and functional recovery after stroke. Neurosci, 2007, 136, 31-40.
- Biernaskie J, Chernenko G, Corbett D Efficacy of rehabilitative experience declines with time following focal ischemic brain injury. J Neurosci, 2004, 24, 1245-1254.
- Kris Langdon PDF
- Carine Nguemeni PDF
- Susan Marzolini PDF (co-supervisor)
- Mariana Gomez-Smith PhD
- Maheen Ceizar PhD (co-supervisor)
- Clarissa Pedrini Schuch PhD (visiting student)
- Krista Hewlett MD/MSc
- Meighan Kelly MD/MSc
Research & Administrative Staff:
- Shirley Granter-Button
- Matthew Jeffers
- Karen McPherson
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