Research

The Department has witnessed a tremendous increase in external research funds in the last several years, and has become one of the highest research intense basic science departments in Canada. The departmental funding situation from 2002 through 2009 is shown in the Figure, and some recent publications of the department core members are listed below.

BMI Research External Funding
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BMI Publications

Mailloux RJ, Harper ME.
Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase.
FASEB J. 2010 Mar 12. [Epub ahead of print]PMID: 20228249 [PubMed - as supplied by publisher]Related citations

Xie X, Stadnisky MD, Coats ER, Ahmed Rahim MM, Lundgren A, Xu W, Makrigiannis AP, Brown MG.
MHC class I D(k) expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine cytomegalovirus. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8754-9. Epub 2010 Apr 26.

Swayne LA, Sorbara CD, Bennett SA.
Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment.
J Biol Chem. 2010 Jun 7. [Epub ahead of print]PMID: 20529862 [PubMed - as supplied by publisher]Free Article

Sasawatari S, Yoshizaki M, Taya C, Tazawa A, Furuyama-Tanaka K, Yonekawa H, Dohi T, Makrigiannis AP, Sasazuki T, Inaba K, Toyama-Sorimachi N. The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.
Immunity. 2010 Feb 26;32(2):200-13. Epub 2010 Feb 11.

Tian R, Wang S, Elisma F, Li L, Zhou H, Wang L, Figeys D.
Rare cell proteomic reactor applied to SILAC based quantitative proteomic study of human embryonic stem cell differentiation. Mol Cell Proteomics. 2010 Jun 8. [Epub ahead of print]PMID: 20530636 [PubMed - as supplied by publisher]Free Article

Seenundun S, Rampalli S, Liu QC, Aziz A, Palii C, Hong S, Blais A, Brand M, Ge K, Dilworth FJ.
UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J. 2010 Apr 21;29(8):1401-11. Epub 2010 Mar 18.

Miura P, Coriati A, Bélanger G, De Repentigny Y, Lee J, Kothary R, Holcik M, Jasmin BJ.
The utrophin A 5'-UTR drives cap-independent translation exclusively in skeletal muscles of transgenic mice and interacts with eEF1A2. Hum Mol Genet. 2010 Apr 1;19(7):1211-20. Epub 2010 Jan 6.

Cheng HY, Alvarez-Saavedra M, Dziema H, Choi YS, Li A, Obrietan K.
Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain. Hum Mol Genet. 2009 Aug 15;18(16):3110-24. Epub 2009 May 28.

Ryan SD, Whitehead SN, Swayne LA, Moffat TC, Hou W, Ethier M, Bourgeois AJ, Rashidian J, Blanchard AP, Fraser PE, Park DS, Figeys D, Bennett SA. Amyloid-{beta}42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proc Natl Acad Sci U S A. 2009 ;106: 20936-20941 [Epub ahead of print] PMID: 19926863

Diallo JS, Boeuf FL, Lai F, Cox J, Vaha-Koskela M, Abdelbary H, Mactavish H, Waite K, Falls T, Wang J, Brown R, Blanchard JE, Brown ED, Kirn DH, Hiscott J, Atkins H, Lichty BD, Bell JC.A High-throughput Pharmacoviral Approach Identifies Novel Oncolytic Virus Sensitizers. Mol Ther. 2010 Apr 13. [Epub ahead of print] PMID: 20389287

Zhong, S., Magnolo, A. L., Sundaram, M., Zhou, H., Yao, E. F., Leo, E. D., Loria, P., Wang, S., Bamji-Mirza, M., Wang, L., McKnight, J., Figeys, D., Wang, Y., Tarugi, P., and Yao, Z. (2010) Nonsynonymous mutations within APOB in human hypobetalipoproteinemia: Evidence for feedback inhibition of lipogenesis and post-endoplasmic reticulum degradation of apolipoprotein B. J. Biol. Chem. 285, 6453-6464.

Seifert EL, Estey C, Xuan JY, Harper ME. Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. J Biol Chem. 2010 Feb 19; 285(8):5748-58.

Labriola JM, Dacosta CJ, Wang S, Figeys D, Smith JC, Sturgeon RM, Baenziger JE.
Phospholipase C activity affinity purifies with the Torpedo nicotinic acetylcholine receptor. J Biol Chem. 2010 Apr 2;285(14):10337-43.

Li L, Wang S, Jezierski A, Moalim-Nour L, Mohib K, Parks RJ, Francesco Retta S, Wang L. A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates self-renewal of human embryonic stem cells. Stem Cells 2010; 28: 247-257

Ye, J., Li, J. Z., Liu, Y., Li, X., Yang, T., Ma, X., Li, Q., Yao, Z., Li, P. (2009) Cideb, an ER and lipid droplet-associated protein, mediates VLDL lipidation by interacting with apolipoprotein B. Cell Metabol. 9, 177-190

Lambert JP, Mitchell L, Rudner A, Baetz K, Figeys D. A novel proteomics approach for the discovery of chromatin-associated protein networks. Mol Cell Proteomics. 2009 Apr; 8(4):870-82.

Fillingham J, Kainth P, Lambert JP, van Bakel H, Tsui K, Peña-Castillo L, Nislow C, Figeys D, Hughes TR, Greenblatt J, Andrews BJ. Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression. Mol Cell. 2009 Aug 14;35(3):340-51.

Sheila Costford*, Sean Crawford*, Robert Dent, Ruth McPherson, and Mary-Ellen Harper. (2009) Increased Susceptibility to Oxidative Damage in Post-Diabetic Human Myotubes.  Diabetologia.  52:2405-2415.

daCosta CJ, Medaglia SA, Lavigne N, Wang S, Carswell CL, Baenziger JE. Anionic lipids allosterically modulate multiple nicotinic acetylcholine receptor conformational equilibria. J Biol Chem. 2009 Dec 4;284(49):33841-9.

Yoshizaki M, Tazawa A, Kasumi E, Sasawatari S, Itoh K, Dohi T, Sasazuki T, Inaba K, Makrigiannis AP, Toyama-Sorimachi N. Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q. Blood. 2009 Aug 20;114(8):1518-27.

Savage, J., Conley, A.J., Blais, A. and Skerjanc, I.S.*, Sox15 regulates pre-skeletal mesoderm formation in P19 cells, Stem Cells, 27(6):1231-43 (2009).

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Last updated: 2010.12.16