Canada Research Chair in Proteomics and Systems Biology .
Institute of systems Biology.
University of Ottawa
Tel: (613) 562-5800, ext. 8674
People and Research
Our research efforts are focused on
the development and application of proteomics, and lipidomics.
In proteomics, we are interested in
developing and applying techniques for the mapping
of protein-protein interactions for proteins relevant to human and the study of quantitative changes in the proteome when limited amount of material is available.
We are currently studying the role of PCSK9 in LDLR degradation, the proteome of Alzheimer and Parkinson diseases, the roles of SMYD proteins in lysine methylation, the proteome of human embryonic stem cells, the proteome of the circadian clock, and acetyltransferases and chromatin remodelling proteins in yeast. More details on our proteomic projects can be found under People and Research Projects.
In lipidomics, we are interested in
developing and applying techniques for the study of changes
in the lipidome during diseases. In particular, we are
targetting specific subclasses of lipids such as PC, PE, and PS and
developing techniques for other classes of lipids as
well. In collaboration with the laboratory of Dr. S. Bennett
we are studying the targetted lipidome in neurodenegrative diseases. More details on our lipidomic projects can be found under People and Research Projects.
Finally, our technology development
efforts are focused on developing proteomics technologies to study
minute levels of proteins, the development of lipidomic technologies
and the development of bioinformatic tools. More details on our technology development projects can be found under People and Research Projects.