People and Research projects

Publications

Research Interests:

Our research efforts are focused on the development and application of proteomics, and lipidomics.

In proteomics, we are interested in developing and applying techniques for the mapping of protein-protein interactions for proteins relevant to human and the study of quantitative changes in the proteome when limited amount of material is available.

We are currently studying the role of PCSK9 in LDLR degradation, the proteome of Alzheimer and Parkinson diseases, the roles of SMYD proteins in lysine methylation, the proteome of human embryonic stem cells, the proteome of the circadian clock, and acetyltransferases and chromatin remodelling proteins in yeast. More details on our proteomic projects can be found under People and Research Projects.

In lipidomics, we are interested in developing and applying techniques for the study of changes in the lipidome during diseases.  In particular, we are targetting specific subclasses of lipids such as PC, PE, and PS and are developing techniques for other classes of lipids as well.  In collaboration with the laboratory of Dr. S. Bennett we are studying the targetted lipidome in neurodenegrative diseases. More details on our lipidomic projects can be found under People and Research Projects.

Finally, our technology development efforts are focused on developing proteomics technologies to study minute levels of proteins, the development of lipidomic technologies and the development of bioinformatic tools. More details on our technology development projects can be found under People and Research Projects.