Contact Information

Manon Levesque Departmental Secretary of Pathology and Laboratory Medicine
451 Smyth road,
Room 4155
Ottawa, Ontario
K1H 8M5

Telephone: 613-562-5422
Fax: 613-562-5442
Email: mlevesq2@uottawa.ca

Sheila Schnupp
Office and Residency Program Administrator (Anatomical)
Telephone: 613-562-5800 ext. 8342
Fax: 613-562-5442
Email: sschnupp@uottawa.ca

John P. Veinot, M.D., F.R.C.P.C (Canada)
Chairman, Department of Pathology and Laboratory Medicine
Tel: 613-562-5422
Fax: 613-562-5442
Email: sschnupp@uottawa.ca

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Esmeralda Celia Marginean, M.D., FRCPC, FACP

Esmeralda Celia Marginean

Associate Professor of Pathology

University of Ottawa, Faculty of Medicine
Staff, Department of Pathology and Laboratory Medicine
The Ottawa Hospital, General Campus
Ottawa, ON
Canada

Tel: 613-737-8899 ext. 79801
Fax: 613-737-8461
Email: cmarginean@ottawahospital.on.ca

Research Interests

Principal investigator – "EGFR, HER2 and c-MET immunohistochemical expression in Gastric Adenocarcinoma: Independent Prognostic Factors?"
Grant from Pathology And Laboratory Medicine (PALM) Research Committee, TheOttawa Hospital, Ottawa, Canada: -$6404.00 (2014)

Principal investigator – "In Search Of an Useful Immunohistochemical Panel to Distinguish Cholangiocarcinoma from Metastatic Gastrointestinal and Pancreatic Adenocarcinomas in Liver"
Grant from Pathology And Laboratory Medicine (PALM) Research Committee, TheOttawa Hospital, Ottawa, Canada: -$8822.00 (2013)

Co-investigator – "STAT3 Expression Concordance in Paired Primary and Metastatic Colorectal Cancers" (PI- Dr. Rachel Goodwin, Medical oncology)
Grant OHRI: $15,000 (2013)

Principal investigator – "Inter-Observer and Intra-Observer Agreement in Diagnosing Dysplasia in Barrett's Esophagus - Comparison of Routine Glass Slides Examination with Digital Images- a Canadian study"
Grant in aid, HL Roche: $ 20,000 (2012)

Principal investigator – "Comparison Of Automated Mitotic Count And Ki67 Scoring On Whole Slide Scanning Using Image Analysis Vs. Estimating On Microscopy For Histologic Grading Of Gastrointestinal And Pancreatic Neuroendocrine Tumors" Grant from Pathology And Laboratory Medicine (PALM) Research Committee, The Ottawa Hospital, Ottawa, Canada: $3,800 (2011)

Principal investigator – "The diagnostic utility of HepPar1, Glypican 3 and IMP3 in distinguishing between hepatocellular carcinoma and benign hepatic lesions"
Grant from Pathology and Laboratory Medicine (PALM) Research Committee, The Ottawa Hospital, Ottawa, Canada: $3,200 (2010)

Principal investigator – "Utility of Immunohistochemistry for Tissue Transglutaminase in the Diagnosis of Celiac Disease on Formalin-Fixed Paraffin-Embedded Tissue". Grant from Pathology And Laboratory Medicine (PALM) Research Committee, The Ottawa Hospital, Ottawa, Canada: $8,200 (2010)

Co-investigator - A Phase II Trial of Pre-operative XELOXIRI Regimen (Capecitabine, Oxaliplatin, Irinotecan) Followed by Combined Modality Capecitabine and Radiation for Locally Resectable Advanced Rectal Cance
Principal investigator – Dr. Jean Maroun, Medical Oncology, The Ottawa Hospital, Ottawa, Canada (2009)

Publications

  • Bennett S, Marginean EC, Paquin-Gobeil M, Wasserman J, Weaver J, Mimeault R, Balaa FK, Martel G.
    Clinical and pathological features of intraductal papillary neoplasm of the biliary tract and gallbladder.
    HPB (Oxford). 2015 Sep;17(9):811-8
  • Paliga A, Marginean H, Tessier-Cloutier B, Purgina B, Jonker D, Marginean EC.The Prognostic Significance of c-MET and EGFR Overexpression in Resected Gastric Adenocarcinomas.Am J Clin Oncol. 2015 Jun 29
  • El Hallani S, Guillaud M, Korbelik J, Marginean EC. Evaluation of Quantitative Digital Pathology in the Assessment of Barrett Esophagus-Associated Dysplasia. Am J Clin Pathol. 2015 Jul;144(1):151-64.
  • Kotha VK, Khandelwal A, Saboo SS, Shanbhogue AK, Virmani V, Marginean EC, Menias CO. Radiologist's perspective for the Meckel's diverticulum and its complications.Br J Radiol. 2014 May;87(1037):20130743
  • Karapetis CS, Jonker D, Daneshmand M, Hanson JE, O'Callaghan CJ, Marginean C, Zalcberg JR, Simes J, Moore MJ, Tebbutt NC, Price TJ, Shapiro JD, Pavlakis N, Gibbs P, Van Hazel GA, Lee U, Haq R, Virk S, Tu D, Lorimer IA. PIK3CA, BRAF, and PTEN Status and Benefit from Cetuximab in the Treatment of Advanced Colorectal Cancer--Results from NCIC CTG/AGITG CO.17.; NCIC Clinical Trials Group and the Australasian Gastro-Intestinal Trials Group. Clin Cancer Res. 2014 Feb 1;20(3):744-53.
  • Shukla T, Jin J, Marginean EC, Saloojee N. Anaplastic large cell lymphoma of the colon in a patient with colonic Crohn disease treated with infliximab and methotrexate. Can J Gastroenterol. 2014 Jan;28(1):11-2.
  • Allison Osmond, Hector Li-Chang, Richard Kirsch, Dimitrios Divaris, Vincent Falck, Dong Feng Liu, Celia Marginean, Ken Newell, Jeremy Parfitt, Brian Rudrick, Heidi Sapp, Sharyn Smith, Joanna Walsh, Fasahat Wasty, David K Driman. Interobserver variability in assessing dysplasia and architecture in colorectal adenomas. J Clin Pathol. 2014 Jul 8
  • 'Callaghan CJ, Marginean C, Zalcberg JR, Simes J, Moore MJ, Tebbutt NC, Price TJ, Shapiro JD, Pavlakis N, Gibbs P, Van Hazel GA, Lee U, Haq R, Virk S, Tu D, Lorimer IA; NCIC Clinical Trials Group and the Australasian Gastro-Intestinal Trials Group. Clin Cancer Res. 2014 Feb 1;20(3):744-53
  • Khandelwal A, Gorsi U, Marginean EC, Papadatos D, George U. Isolated granulomatous hepatitis-a histopathological surprise mimicking cholangiocarcinoma in ulcerative colitis. Ann Hepatol. 2013 Mar-Apr;12(2):332-5.
  • Bradshaw SH, Pidutti D, Gravel DH, Song X, Marginean EC, Robertson SJ. Predicting OncoDx Recurrence Scores With Immunohistochemical Markers. Appl Immunohistochem Mol Morphol. 2013 Feb 28.
  • Gill S, Berry S, Biagi J, Butts C, Buyse M, Chen E, Jonker D, Mărginean C, Samson B, Stewart J, Thirlwell M, Wong R, Maroun JA.Progression-free survival as a primary endpoint in clinical trials of metastatic colorectal cancer. Curr Oncol. 2011 Oct;18 Suppl 2:S5-S10.
  • Martel G, Alsharif  J, Aubin JM, Marginean C, Mimeault R, Fairfull-Smith  R, Mohammad  M, , Balaa F. The management of hepatobiliary cystadenomas: lessons learned". Hepato-Pancreato-Biliary HPB (Oxford). 2012 Dec 6
  • Yarom N, Marginean C, Moyana T, Gorn-Hondermann I, Birnboim HC, Marginean H, Auer RC, Vickers M, Asmis TR, Maroun J, Jonker D.EGFR expression variance in paired colorectal cancer primary and metastatic tumors. Cancer Biol Ther. 2010 Sep;10(5):416-21.
  • Nguyen BN, Gomes MM, Marginean CE, Cote J, Mai KT. A Comparative Immunohistochemical Study Of Serous And Mucinous Cystic Neoplasms Of The Pancreas: Similar Stroma Phenotype Suggesting A Possible Histopathogenetic Relationship. Pancreas. 2010 Sep 28
  • Asmis T, Balaa F, Scully L, Papadatos D, Marginean C, Fasih N, Shaw-Stiffel T, Goel R. Diagnosis and management of hepatocellular carcinoma: results of a consensus meeting of The Ottawa Hospital Cancer Centre. Curr Oncol. 2010 Apr;17(2):6-12
  • Fasih N, Shanbhogue AK, Thipphavong S, Surabhi VR, Papadatos D, Marginean C. Gamut of focal fatty lesions in the liver: imaging manifestations with emphasis on magnetic resonance imaging. Curr Probl Diagn Radiol. 2010 Jul-Aug;39(4):137-51.
  • Bandarchi. B., Marginean C, Hafezi S, Zubovits J, Rasty G . D2-40, a Novel Immunohistochemical Marker in Differentiating Dermatofibrosarcoma Protuberans and Dermatofibroma. Mod Pathol. 2010 Mar; 23(3):434-8.

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Last updated: 2015.09.08