Contact Information

John P. Veinot, M.D., F.R.C.P.C (Canada)
Chairman, Department of Pathology and Laboratory Medicine
Tel: 613-562-5422
Email: sschnupp@uottawa.ca

Sheila Schnupp
Office and Residency Program Administrator (Anatomical)
Telephone: 613-562-5800 ext. 8342
Email: sschnupp@uottawa.ca

Manon Levesque Undergraduate Program and Office Coordinator
451 Smyth road,
Room 4155
Ottawa, Ontario
K1H 8M5

Tel: 613-562-5422
Email: mlevesq2@uottawa.ca

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Seymour Brownstein

Dr Seymour Brownstein

M.D. (McGill), F.R.C.S. (Canada)
Full Professor, Department of Ophthalmology and Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa
Staff Ophthalmologist, Ocular Pathologist and Scientist, University of Ottawa Eye Institute, 501 Smyth Road, Suite W6213, Ottawa, K1H 8L6
Associate Clinician Scientist, Ottawa Hospital Research Institute

Telephone: 613-737-8824 (Monday through Thursday)
Fax: 613-737-8826
Email: sbrownstein@ohri.ca

Areas of Interest and Expertise

  • Directing Ocular Pathology Diagnostic Research Laboratory
  • Teaching of Ophthalmic Pathology (Undergraduate, Post-Graduate, and Staff)
  • Fellowship Program in Ophthalmic Pathology with Clinical and Basic Research

Research

Our Ophthalmic Pathology unit is very active in both basic science and clinical research with over 12 ongoing projects involving numerous collaborative studies. These projects include ocular neoplasia, inflammations and infections, degenerations, vascular disorders, infiltrations, congenital and hereditary anomalies, glaucoma, and trauma. The basic research at present includes immunohistochemical analyses on both ocular melanocytic and eyelid sebaceous neoplasms and is geared for presentation at the major meetings in my field of expertise, including ARVO, AAO/AAOOP and COS/COPS.

Laboratory work

The University of Ottawa Registry of Ophthalmic Pathology, which was initiated in 1971, receives ocular specimens from the hospitals associated with the University of Ottawa, many of the Ottawa regional hospitals, and from medical institutions across Canada and occasionally internationally.

Teaching

This includes undergraduate Medical School and the Ophthalmic Medical Technology B.Sc. Program at the University of Ottawa and especially postgraduate residency education. Didactic lectures using PowerPoint slides to demonstrate the clinical and corresponding pathologic findings of most ocular conditions are delivered annually in the postgraduate ophthalmology teaching course which is augmented by Grand Rounds, Professor Rounds and the “mock” oral examinations.

Fellowship

The University of Ottawa Eye Institute offers a one year funded Fellowship in Ophthalmic Pathology beginning in July each year. This position is open to individuals either prior to a residency in Ophthalmology or Pathology including immediately after graduation from medical school or to those who have completed their ophthalmology, pathology or other residency. The Fellow has the opportunity to learn to perform the various procedures in the Ophthalmic Pathology Laboratory including gross, light, and electron microscopy, photomicroscopy, and immunohistochemistry. He/She participates in a number of clinically orientated research projects involving ophthalmic pathology. The Fellow has the opportunity to attend many local teaching sessions, rounds and conferences related to both specialties and generally participates in at least some of these rounds and conferences. The Fellow is also involved in the teaching program for our residents and the elective medical school students who rotate through the laboratory. Overall, we provide a very diversified and stimulating year with many research opportunities which should augment the future career of any of our fellows whether they decide to devote themselves to academic ophthalmology or pathology, another fellowship, or general ophthalmologic or pathologic practice.

Recent Publications (2008-2014)

  • Gooi P, Rawlings N, Brownstein S. Temporal arteritis: a dilemma in clinical and pathological diagnosis. Can J Ophthalmol 2008; 43: 119-120.
  • Gooi P, Lee-Wing M, Brownstein S, El-Defrawy S, Jackson WB, Mintsioulis G. Acanthamoeba keratitis: Persistent organisms after one year of chlorhexidine therapy. Cornea 2008; 27: 246-248.
  • Sher JH, Gooi P, Dubinski W, Brownstein S, El-Defrawy S, Nash WA. Comparison of the incidence of opacification of Hydroview hydrogel intraocular lens with the viscosurgical device used during surgery. J Cataract Refract Surg 2008; 34: 459-464.
  • O’Connor MD, Talbot R, Brownstein S, Rawlings N, Damji KF: Histopathology in a dissecting conjunctival filtering bleb. Can J Ophthalmol 2008; 43: 114-115.
  • Belliveau MJ, Brownstein S, Jordan DR. Fibrous histiocytoma presenting as a medial canthal mass. Can J Ophthalmol 2008; 43: 250.
  • Spitellie PH, Jordan DR, Brownstein S, Gooi P, Burns BF. Sinonasal undifferentiated carcinoma with a frozen globe. Ophth Plast Reconstr Surg 2008: 24: 225-227.
  • Jordan DR, Belliveau MJ, Brownstein S, McEachren T, Kyrollos M. Medial canthal tophus. Ophth Plast Reconstr Surg 2008; 24: 403-404.
  • Spitellie PH, Jordan DR, Gooi P, Brownstein S, Burns BF. Primary localized amyloidosis simulating a lymphoproliferative disorder. Ophth Plast Reconstr Surg 2008; 24: 417-419.
  • Varma, DK, Brownstein S, Hodge WG, Faraji H. Generalized posterior keratoconus: Clinical pathologic correlations. Can J Ophthalmology 2008; 43: 480-482.
  • Jordan DR, Belliveau MJ, Brownstein S, Padmore RF. Osteogenesis with hematopoiesis in a hydroxyapatite orbital implant simulating infection. Ophth Plast Reconstr Surg 2009; 25: 72-74.
  • Liao W, Brownstein S, Clark W, Leonard B, Jordan DR. Retinoblastoma presenting as panophthalmitis in a young child. Clin Surg Ophthalmol 2009; 27: 23-26.
  • Belliveau MJ, Brownstein S, Schneider RJ, Conlon MR. Unsuspected adenocarcinoma of the nonpigmented ciliary epithelium in a blind painful eye. Can J Ophthalmol 2009; 44: 105-106.
  • Belliveau MJ, Brownstein S, Agapitos P, Font RL. Ultrastructural features of posterior crocodile shagreen of the cornea. Surv Ophthalmol. 2009; 54: 569-575.
  • Belliveau MJ, Brownstein S, Jackson WB, Yucel. Bilateral conjunctival lymphangiectasia in Klippel-Trenaunay-Weber syndrome. Arch Ophthalmol. 2009; 127: 1057-1058.
  • Liao W, Jolly SS, Brownstein S, Jordan DR, Gilberg S, Prokopetz R. Lupus miliaris disseminatus faciei of the eyelids: report of two cases. Ophthal Plast Reconstr Surg 2010; 26: 59-61.
  • Belliveau M, Rocha G, Manchur A, Brownstein S. Bilateral Descemet’s stripping with endothelial keratoplasty for posterior polymorphous corneal dystrophy in a young phakic patient. Can J Ophthalmol 2010; 45: 180-181.
  • Belliveau MJ, Coupel D, Brownstein S, Jordan WR, Prokopetz R. Infundibulocystic basal cell carcinoma of the eyelid in basal cell nevus syndrome. Ophthal Plast Reconstr Surg 2010; 26: 147-152.
  • Manusow JS, Brownstein S, Belliveau MJ. Bilateral massive embryotoxon. J Pediatr Ophthalmol Strab 2010; 45: 180-181.
  • Jastrzebski A, Brownstein S, Jordan DR. Non-distensible venous malformation of the orbit. Clin Surg Ophthalmol 2010; 28: 286-290.
  • Manusow J, Brownstein S, Jordan DR. Osseous metaplasia with formation of hematopoietic bone marrow in a blind, painful eye. Ophthal Plast Reconstr Surg 2011; 27:e81-3.
  • Jastrzebski A, Brownstein S, Manusow J, Rubab S. Isolated conjunctival lymphangioma. Can J Ophthalmol 2011; 46: 369-370.
  • Lam K, Brownstein S, Jastrzebski A, Jordan DR, Burns BF. Bilateral benign reactive lymphoid hyperplasia of the conjunctiva in a pediatric patient. J Pediatr Ophthalmol Strabismus 2011 Dec 13; 48 Online: e69-71.
  • Lam K, Brownstein S, Jordan DR. Ocular metastatic breast cancer. Clinical Surg Ophthalmol (Jan.) 2012; 30: 24-29.
  • Jastrzebski A, Brownstein S, Jordan DR, de Nanassy J. Dacryops of Krause’s gland in the inferior fornix in a child. Arch Ophthalmol (Feb.) 2012; 130: 252-254.
  • Jastrzebski A, Brownstein S, Jordan DR, Burns BF. Bilateral subconjunctival masses due to orbital fat prolapse. Can J Ophthalmol 2012 (Feb.); 47: 81-82.
  • Belliveau M, Liao W, Brownstein S, Manusow JS, Jordan DR, Gilberg S, Mintsioulis G. Myxomatous corneal degeneration: A clinicopathological study of 6 cases and a review of the literature. Surv Ophthalmol (May-June) 2012; 57: 264-271.
  • Al-Abri M, Britton WA, Manusow JS, Brownstein S, Patel V, Hurley B, Agapitos P. Restoration of vision following surgical removal of an intraocular needlefish jaw. Retinal Cases and Brief Reports (Summer) 2012; 6: 298-300.
  • Jastrzebski A, Brownstein S, Jordan DR, Gilberg SM: Histochemical analysis and immunohistochemical profile of mucoepidermoid carcinoma of the conjunctiva. Saudi J Ophthal (April/June) 2012; 26: 205-210.
  • Manusow J, Brownstein S, Nijhawan N, Jackson WB, DeAngelis DD. Sebaceous carcinoma of the eyelid: An elusive diagnosis. Can J Pathol (summer) 2012 4: 59-61.
  • Dollin M, Jastrzebski A, Bhatti A, Graham L, O’Connor MD, Brownstein S. An unusual corneal limbal foreign body: Ostracoda shell. Can J Ophthalmol. epub 46 Dec. 2012.
  • Lam K, Brownstein S, Baig K, Grynspan D, Farmer J. Inverted papilloma associated with subepithelial nevus of the limbal conjunctiva in a child. J Pediatr Ophthalmol Strabismus. E-publication (Dec.) 2012.
  • Milne R, Brownstein S. Advanced glycation products and diabetic retinopathy. Amino Acids. (June) 2013; 44: 1397-1407.
  • Lam K, Brownstein S, Jordan DR, van der Jagt R, Jastrzebski A, Dionne MA. Bilateral necrobiotic xanthogranuloma of the eyelids followed by a diagnosis of multiple myeloma 20 years later. Ophthal Plast Reconstr Surg. 2013: 29(5): e 119-120.
  • Lam K, Brownstein S, Jordan DR, Jastrzebski A. Dacryops: A series of 5 cases and a proposed pathogenesis. JAMA Ophthalmol. (July) 2013; 131:929-932.
  • Jiang K, Brownstein S, Sekhon HS, Laurie SA, Lam K, Gilberg S, Britton W: Ocular metastasis of lung adenocarcinoma with ELM4-ALK translocation: A case report with a review of the literature. Saudi J Ophthalmol. (July) 2013: 27, 187–192.
  • Jiang K, Brownstein S, Lam K, Baig K, Toye B. Clinicopathological case reports of Alternaria and Fusarium keratitis in Canada. Can J Ophthalmol 2013: 48(6): e 151-154.
  • Jiang K, Brownstein S, Lam K, Burns BF, Farmer J. Usefulness of a red chromagen in the diagnosis of melanocytic lesions of the conjunctiva. JAMA Ophthalmology. 2014:132(5):622-629.
  • Jiang K, Brownstein S, Lam K, Chow D, Jackson WB. Posterior Amorphous Amyloid Degeneration. JAMA Ophthalmol. 2014; 132(6): 736.
  • Jiang K, Brownstein S, Toye B, Ali-Ridha A, Mintsioulis G. Mycobacterium chelonae keratitis in a 3-decade old corneal graft. JAMA Ophthalmol. 2014; 132(8): 962.
  • Jordan DR, Stoica B, Brownstein S, Ali-Rhida A. Intratarsal keratinous cyst mimicking a large chalazion. Can J Ophthalmol 2014; 49 Dec.: e-publication. In press.

Presentations (2011-2014)

2011

  • Greater New York Ophthalmic Pathology Visiting Professor, New York City, Feb. 2011.
    • Brownstein S. Normal anatomy and histology of the conjunctiva.
    • Brownstein S. Pathology of conjunctival inflammation and degeneration.
    • Brownstein S. Pathology of proliferative conditions of the conjunctiva.
  • University of Ottawa Department of Laboratory Medicine (Pathology) Annual Research Day, Ottawa, ON, April 2011.
    • Jastrzebski A, Brownstein S, Jordan DR, Gilberg SM. Unsuspected ciliary body and choroidal melanoma diagnosed after evisceration and enucleation: A series of cases seen at the Ottawa Eye Institute from 1996-2010.
  • University of Ottawa Department of Ophthalmology Annual Research Day, Ottawa, ON, May 2011.
    • Jastrzebski A, Brownstein S, Jordan DR, Gilberg SM, Leonard B. Unsuspected ciliary body and choroidal melanoma diagnosed after evisceration and enucleation: A series of cases seen at the Ottawa Eye Institute from 1996-2010.
  • Canadian Ophthalmic Pathology Society, Vancouver, BC, June 2011.
    • Brownstein S, Manusow JS, Nijhawan N, Jackson WB, DeAngelis, Krema H. Sebaceous carcinoma of the eyelid: an elusive diagnosis.
  • Canadian Ophthalmological Society, Vancouver, BC, June 2011.
    • Jastrzebski A, Brownstein S, Jordan DR, Gilberg SM, Leonard B. Unsuspected ciliary body and choroidal melanoma diagnosed after evisceration and enucleation: A series of cases seen at the University of Ottawa Eye Institute from 1996-2010
  • Sally Letson Symposium, Ottawa, ON, Sept. 2011.
    • Brownstein S. Pathological highlights of selected glaucomas.
  • American Association of Ocular Oncologists and Pathologists (AAOOP, Satellite meeting of American Academy of Ophthalmology), Orlando, FL, Nov. 2011.
    • Brownstein S, Jastrzebski A, Jordan DR, Gilberg SM, Leonard B, Hurley BR. Unsuspected and misdiagnosed ciliary body and choroidal melanoma diagnosed after enucleation and evisceration: Review of cases in the Ottawa-Gatineau region from 1996-2010.
  • Eastern Ophthalmic Pathology Society, Buenos Aires, Argentina, Nov. 2011.
    • Brownstein S, Jastrzebski A, Jordan DR, de Nanassy J. Dacryops of Krause’s gland in the inferior fornix in a child.

2012

  • Greater New York Ophthalmic Pathology Visiting Professor, New York City, Jan. 2012.
    • Brownstein S. Normal anatomy and histology of the cornea.
    • Brownstein S. Pathology of corneal inflammation and systemic associations.
    • Brownstein S. Pathology of corneal degenerations and dystrophies.
  • University of Ottawa Department of Laboratory Medicine (Pathology) Annual Research Day, Ottawa, Ontario, April 2012.
    • Lam K, Brownstein S, Jastrzebski A, Jordan DR, de Nanassy J. Orbital dacryops. A series of 6 cases with a proposed pathogenesis. (Prize for second best paper by a senior resident or fellow).
  • Verhoeff-Zimmerman Society, Waikoloa, Hawaii, April 2012.
    • Brownstein S, Jastrzebski A, Jackson WB, Zia S, Lam K. Post-vaccination herpes zoster keratitis with descemetocoele.
  • Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, May 2012.
    • Brownstein S, Lam K, Jastrzebski A, Jordan DR, de Nanassy J. Dacryops: A series of six cases and a review of the literature.
    • Lam K, Brownstein S, Manusow J, Jastrzebski A, Jackson WB, Gilberg S, Sassani JW. Histological and immunohistochemical comparison of secondary post-traumatic amyloidosis and polymorphic amyloid degeneration of the cornea.
  • University of Ottawa Department of Ophthalmology Annual Research Day, Ottawa, ON, May 2012.
    • Lam K, Brownstein S, Jastrzebski A, Jordan DR, de Nanassy J. Orbital dacryops. A series of 6 cases with a proposed pathogenesis.
  • Canadian Ophthalmic Pathology Society, Toronto, ON, June 2012.
    • Brownstein S, Jastrzebski A, Ziai S, Jackson WB, Jastrzebski A, Mintsioulis G, Lam K: Herpes zoster ophthalmicus followed by VZV vaccine and subsequent perforating descemetocoele.
    • Lam K, Brownstein S, Jordan DR. Ocular metastatic breast cancer.
  • Canadian Ophthalmological Society, Toronto, ON, June 2012.
    • Ziai S, Jackson WB, Jastrzebski A, Brownstein S, Mintsioulis G, Lam K: Herpes zoster ophthalmicus followed by VZV vaccine and subsequent perforating descemetocoele.
    • Lam K, Brownstein S, Jastrzebski A, Jordan DR. Orbital dacryops.
  • Hadassah University Medical Center Department of Ophthalmology Visiting Professor, Jerusalem, Israel, July 2012.
    • Brownstein S. Normal anatomy and histology of the conjunctiva.
    • Brownstein S. Pathology of conjunctival inflammation and degeneration.
    • Brownstein S. Pathology of proliferative conditions of the conjunctiva.
    • Brownstein S. Grand Rounds. Interactive CPCs.
  • Harvard Medical School/New England Ophthalmic Pathology Visiting Professor, Boston, Mass., October 2012.
    • Brownstein S. Normal anatomy and histology of the cornea.
    • Brownstein S. Pathology of corneal inflammation and infections.
    • Brownstein S. Pathology of corneal degenerations and dystrophies.
  • Eastern Ophthalmic Pathology Society, Miami, FL Oct. 2012 (also, Moderator).
    • Brownstein S. Multiple myeloma 20-years after diagnosis of necrobiotic xanthogranuloma of the medial canthi.
  • American Association of Ocular Oncologists and Pathologists (AAOOP, Satellite meeting of American Academy of Ophthalmology), Chicago, IL, Nov. 2012.
    • Brownstein S, Lam K, Jordan DR, Jastrzebski A. Orbital dacryops. Series of 5 cases with a proposed pathogenesis.

2013

  • University of Ottawa Department of Laboratory Medicine (Pathology) Annual Research Day, Ottawa, Ontario, April 2013.
    • Jiang K, Brownstein S, Lam K, Jastrzebski A, Burns BF, Farmer JK. Immunohistochemical and histochemical analysis of conjunctival melanocytic lesions (Awarded second prize for a R1-3 Resident).
  • Association for Research in Vision and Ophthalmology, Seattle, WA, May 2013 (also, Moderator of ocular oncology and pathology session).
    • Brownstein S, Jiang K, Lam K, Jastrzebski A, Burns BF, Farmer JK. Immunohistochemical and histochemical analysis of conjunctival melanocytic lesions.
  • University of Ottawa Department of Ophthalmology Annual Research Day, Ottawa, ON, May 2013.
    • Jiang K, Brownstein S, Lam K, Jastrzebski A, Burns BF, Farmer JK. Immunohistochemical and histochemical analysis of conjunctival melanocytic lesions. (Awarded first prize for a Resident or Fellow).
  • American Society of Oculo-Plastic and Reconstructive Surgeons, Newport, RI, June 2013.
    • Mehta S, Oestreicher JH, Brownstein S, Jiang, Nijhawan N. Regression of sebaceous carcinoma of the orbit after small incisional biopsy.
  • Canadian Ophthalmic Pathology Society, Montreal, QC, June 2013 (also, Moderator of orbital and lacrimal system session III: 10 papers).
    • Brownstein S, Jiang K: Anterior segment mystery case (Corneal parasite).
    • Brownstein S, Jastrzebski A, Jordan DR, Burns BK. Bilateral intraconal orbital fat prolapse.
    • Jiang K, Brownstein S, Sekhon H, Britton W, Laurie S, Gilberg S: Lung adenocarcinoma in a non-smoker presenting as an intraocular neoplasm. Jastrzebski A, Brownstein S, Jordan DR. Upper eyelid and anterior orbital vascular anomaly.
    • Mehta S, Oestreicher JH, Brownstein S, Jiang, Nijhawan N. Regression of sebaceous carcinoma of the orbit after small incisional biopsy.
  • Canadian Ophthalmological Society, Montreal, QC, June 2013.
    • Brownstein S. Sebaceous carcinoma (by invitation by the COS).
    • Jiang K, Brownstein S, Mintsioulis G, Lam K: Fungal keratitis in Canada.
    • Manusow J, Brownstein S, Lam K, Jastrzebski A, Mintsioulis G, Gilberg S, Sassani J, Jackson, WB. Traumatic secondary corneal secondary amyloidosis.
  • Hadassah University Medical Center Department of Ophthalmology Visiting Professor, Jerusalem, Israel, July 2013.
    • Brownstein S. Grand Rounds. Interactive CPCs.
    • Brownstein S. Normal anatomy and histology of the cornea.
    • Brownstein S. Pathology of corneal inflammation
    • Brownstein S. Pathology of corneal degeneration.
    • Brownstein S. Pathology of corneal dystrophies
  • Eastern Ophthalmic Pathology Society, NYC, NY, Oct. 2013.
    • Brownstein S, Jiang K, Toye B, Baig K, Mintsioulis G. Fungal keratitis in Canada: 3 cases.
  • American Association of Ocular Oncologists and Pathologists (AAOOP, Satellite meeting of American Academy of Ophthalmology [AAO]), New Orleans, LA, Nov. 2013.
    • Brownstein S, Jiang K, Lam K, Jastrzebski A, Burns BF, Farmer JK. Immunohistochemical and histochemical analysis of conjunctival melanocytic lesions.

2014

  • World Congress of Ophthalmology (WOC), Tokyo, Japan, April 2014
    • Brownstein S. Ocular pathology: The final word (in a symposium on innovative technologies in ophthalmology by 6 Canadian ophthalmologists, by invitation by the WOC and COS).
  • Association for Research in Vision and Ophthalmology, Orlando, FL, May 2014.
    • Ali-Ridha, A, Brownstein S, Jiang K, Burns BF, Bianco P, Farmer JK. Immunohistochemical and histochemical analysis of sebaceous carcinoma of the eyelid.
  • University of Ottawa Department of Ophthalmology Annual Research Day, Ottawa, ON, May 2014.
    • Ali-Ridha, A, Brownstein S, Jiang K, Burns BF, Farmer JK. Immunohistochemical and histochemical analysis of sebaceous carcinoma of the eyelid.
  • Canadian Ophthalmic Pathology Society/Canadian Ophthalmologic Society, Halifax, NS, June 2014. Moderator of Cornea and Conjunctive Section I:8 papers.
    • Brownstein S, Jiang K, Ali-Ridha, Toye B, Mintsioulis G: Mycobacterium cheloneae keratitis in a 3-decade-old graft.
  • Hadassah University Medical Center Department of Ophthalmology Visiting Professor, Jerusalem, Israel, July 2014.
    • Brownstein S. Grand Rounds. Interactive CPCs.
    • Brownstein S. Pathology of ocular suppurative inflammation.
    • Brownstein S. Pathology of nongranulomatous inflammation.
    • Brownstein S. Pathology of granulomatous inflammation.
    • Brownstein S. Pathology of ocular parasitic disorders.
  • Eastern Ophthalmic Pathology Society, Baltimore, MD, Nov. 2014.
    • Brownstein S, Ali-Ridha A, O’Connor M. Conjunctival benign xanthomatous histiocytoma in a youth.

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