CORBETT, Dale, Ph.D.
Faculty of Medicine
451 Smyth Road, Ottawa, ON
Tel.: 613-562-5800 ext. 8177
Scientific Director & CEO
Heart & Stroke Foundation
Canadian Partnership for Stoke Recovery
Link to CV
In Canada there are ~62,000 strokes per year. A majority of stroke survivors are left with life long disabilities making stroke the leading cause of permanent neurological disability. Recent findings suggest that stroke injury triggers restorative processes to create a cerebral milieu similar to that of early brain development, a period characterized by rapid neuronal growth and neuroplasticity. In my lab we attempt to optimally engage these neuroplasticity/re-organizational processes to better enhance post-stroke recovery of function. We use sophisticated animal models of stroke that lend themselves to clinical translation. Examples of current research projects:
- Use of novel combination therapies including growth and recovery promoting drugs thought to be critical for mediating recovery of function in stroke
- Determining the effects of rehabilitation on the reorganization of cortical maps, corticospinal pathways and motor recovery, with special reference to the dose, sequence and timing of rehabilitation
- Mobilizing endogenous stem and neuronal precursor cells (NPCs) in neonatal and adult stroke models. The aim is to encourage NPCs to migrate to the injury site and reorganize remaining circuitry to take over lost function
- Development of an animal model of vascular cognitive impairment that includes disease co-morbidity factors induced by unhealthy diets and lack of exercise. Of particular interest are the alterations in the microvasculature of the brain
- Exercise as an intervention to promote stroke recovery and cognitive function
Canadian Institutes of Health Research (CIHR); Heart & Stroke Foundation of Canada; Heart & Stroke Foundation Canadian Partnership for Stroke Recovery; Canadian Consortium on Neurodegeneration in Aging (CCNA); Canadian Vascular Network
- Jeffers MS, Hoyles A, Morshead C, Corbett D. Epidermal growth factor and erythropoietin infusion accelerates functional recovery in combination with rehabilitation. Stroke, 2014, 45, 1856-1858.
- Hewlett KA, Kelly MH, Corbett D. ‘Not-so-minor’ stroke: Lasting psychosocial consequences of anterior cingulate cortical ischemia in the rat. Exper Neurol, 2014, 261, 543-550.
- Clarke J, Langdon K, Corbett D. Early post-stroke experience differentially alters peri-infarct Layer II and III cortex. J Cereb Blood Flow Metab, 2014, 34, 630-637.
- Cordova CA, Jackson D, Langdon KD, Hewlett KA, Corbett D. Impaired executive function following ischemic stroke in the rat medial prefrontal cortex. Behav Brain Res, 2013, 258, 106-111.
- Langdon KD, Granter-Button S, Harley CW, Moody-Corbett F, Peeling J, Corbett D. Cognitive rehabilitation reduces cognitive impairment and normalizes hippocampal CA1 architecture in a rat model of vascular dementia. J Cereb Blood Flow Metab, 2013, 33, 872-879.
- Krakauer J, Carmichael ST, Corbett D, Wittenberg G. Getting neurorehabilitation right – What can we learn from animal models? Neurorehabil & Neural Repair, 2012, 26, 923-931.
- Langdon KD, Corbett D. Improved working memory following novel combinations of physical and cognitive activity. Neurorehabil & Neural Repair, 2012, 26, 523-532.
- MacLellan CL, Keough MB, Granter-Button S, Chernenko GA, Butt S, Corbett D. A critical threshold of rehabilitation involving brain-derived neurotrophic factor is required for post-stroke recovery. Neurorehabil & Neural Repair, 2011, 25, 740-748.
- Wang Y, Cooke, MJ, Lapitsky Y, Wylie RG, Sachewsky N, Corbett D, Morshead CM, Shoichet MS. Transport of epidermal growth factor in stroke-injured brain. J Control Release, 2010, 149, 225-235.
- Ploughman M, Windle V, White N, MacLellan CL, Doré JJE, Corbett D. Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke, 2009, 40, 1490-1495.
- Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behavior. Nat Rev Neurosci, 2009, 10, 861-872.
- Biernaskie J, Chernenko G, Corbett D. Efficacy of rehabilitative experience declines with time following focal ischemic brain injury. J Neurosci, 2004, 24, 1245-1254.
- Jessy Livingston-Thomas PDF
- Mariana Gomez-Smith PhD
- Maheen Ceizar PhD (co-supervisor)
- Paul Nelson MSc
- Sabina Antonescu MSc
- Sudhir Karthikeyan MSc
- Meighan Kelly MD/MSc
- Therese Gagnon BSc
- Emily Schaefer BSc
- Amanda Nitschke BHSc
Recent Visiting International Students:
- Christophe Celma MSc (France)
- Jannis Achenbach MD (Germany)
- Sabrina Schetat BSc (Germany)
- Clarissa Pedrini Schuch PhD (Brazil)
Research & Administrative Staff:
- Matthew Jeffers, Laboratory Manager (firstname.lastname@example.org)
- Anthony Carter
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